Zangoose are fairly large mammalian Pokémon that have the characteristics of mongooses and cats. They are mostly white in color, but possess deep red markings on the face, chest and paws, which have sharp pointed turns and edges. These markings make it appear that it has been involved in a vicious fight and is covered in blood and scars. They have two long, sharp black claws on their forepaws that are their main weapons. In earlier sprites, these claws were purple in color. Zangoose has pink eyes, small tufts of white fur on its shoulders, and a large, thick furry white tail. It also has a pattern of four pink circles on the underside of its three-toed feet in a 'paw-pad'-like arrangement.
Zangoose are bitter enemies with Seviper, and the two will battle each other to the end. It is suggested this rivalry has lasted for ages. It will usually walk on all fours but when angry it will stand on its hind legs.
Zangoose is an active hunter, and its prey may include Seviper.